Tick as a model for the study of a primitive complement system.
Adv Exp Med Biol
; 710: 83-93, 2012.
Article
em En
| MEDLINE
| ID: mdl-22127888
ABSTRACT
Ticks are blood feeding parasites transmitting a wide variety of pathogens to their vertebrate hosts. The transmitted pathogens apparently evolved efficient mechanisms enabling them to evade or withstand the cellular or humoral immune responses within the tick vector. Despite its importance, our knowledge of tick innate immunity still lags far beyond other well established invertebrate models, such as drosophila, horseshoe crab or mosquitoes. However, the recent release of the American deer tick, Ixodes scapularis, genome and feasibility of functional analysis based on RNA interference (RNAi) facilitate the development of this organism as a full-value model for deeper studies of vector-pathogen interactions.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas do Sistema Complemento
/
Ixodes
/
Proteínas de Insetos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article