Improving circulatory disturbance in transient abnormal myelopoiesis.
J Pediatr Hematol Oncol
; 34(4): e149-51, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22134612
ABSTRACT
Transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) is characterized by circulating blast cells in the blood. TAM usually resolves spontaneously, but several studies have associated this condition with early death, focusing on the development of effective treatments. We report the case of a neonate with DS who had TAM and novel GATA1 mutation. Although the patient eventually died of hepatic failure, exchange blood transfusion and low-dose cytarabine treatment dramatically improved pulmonary hypertension and acute renal failure refractory to conventional therapy. Such a blast-reducing approach might be useful for improving circulatory disturbances in neonates with DS and TAM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transfusão de Sangue
/
Falência Hepática
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Síndrome de Down
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Citarabina
/
Mielopoese
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Doenças do Recém-Nascido
/
Antimetabólitos Antineoplásicos
Limite:
Humans
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article