The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate.
PLoS Genet
; 7(12): e1002403, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-22144916
ABSTRACT
Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
RNA de Transferência
/
Diferenciação Celular
/
Folículo Piloso
/
Epiderme
/
Metiltransferases
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article