Secondary metabolites from the roots of Neolitsea daibuensis and their anti-inflammatory activity.
J Nat Prod
; 74(12): 2489-96, 2011 Dec 27.
Article
em En
| MEDLINE
| ID: mdl-22148193
ABSTRACT
Bioassay-guided fractionation of the roots of Neolitsea daibuensis afforded three new ß-carboline alkaloids, daibucarbolines A-C (1-3), three new sesquiterpenoids, daibulactones A and B (4 and 5) and daibuoxide (6), and 20 known compounds. The structures of 1-6 were determined by spectroscopic analysis and single-crystal X-ray diffraction. Daibucarboline A (1), isolinderalactone (7), 7-O-methylnaringenin (8), and prunetin (9) exhibited moderate iNOS inhibitory activity, with IC50 values of 18.41, 0.30, 19.55, and 10.50 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Carbolinas
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Anti-Inflamatórios não Esteroides
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Lauraceae
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Alcaloides
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article