Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.
Dement Geriatr Cogn Disord
; 32(4): 241-9, 2011.
Article
em En
| MEDLINE
| ID: mdl-22156442
ABSTRACT
BACKGROUND/AIMS:
Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). We examined the relation of polymorphisms in the gene for the estrogen receptor-beta (ESR2) to the risk of AD in women with Down syndrome.METHODS:
Two hundred and forty-nine women with Down syndrome, 31-70 years of age and nondemented at baseline, were followed at 14- to 18-month intervals for 4 years. Women were genotyped for 13 single-nucleotide polymorphisms (SNPs) in the ESR2 gene, and their association with AD incidence was examined.RESULTS:
Among postmenopausal women, we found a 2-fold increase in the risk of AD for women carrying 1 or 2 copies of the minor allele at 3 SNPs in introns seven (rs17766755) and six (rs4365213 and rs12435857) and 1 SNP in intron eight (rs4986938) of ESR2.CONCLUSION:
These findings support a role for estrogen and its major brain receptors in modulating susceptibility to AD in women.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Down
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Receptor beta de Estrogênio
/
Doença de Alzheimer
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article