Vertebrate-like regeneration in the invertebrate chordate amphioxus.
Proc Natl Acad Sci U S A
; 109(2): 517-22, 2012 Jan 10.
Article
em En
| MEDLINE
| ID: mdl-22203957
ABSTRACT
An important question in biology is why some animals are able to regenerate, whereas others are not. The basal chordate amphioxus is uniquely positioned to address the evolution of regeneration. We report here the high regeneration potential of the European amphioxus Branchiostoma lanceolatum. Adults regenerate both anterior and posterior structures, including neural tube, notochord, fin, and muscle. Development of a classifier based on tail regeneration profiles predicts the assignment of young and old adults to their own class with >94% accuracy. The process involves loss of differentiated characteristics, formation of an msx-expressing blastema, and neurogenesis. Moreover, regeneration is linked to the activation of satellite-like Pax3/7 progenitor cells, the extent of which declines with size and age. Our results provide a framework for understanding the evolution and diversity of regeneration mechanisms in vertebrates.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Cauda
/
Cordados não Vertebrados
Tipo de estudo:
Prognostic_studies
Limite:
Animals
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article