Risk factors for disease progression in advanced jejunoileal neuroendocrine tumors.
Neuroendocrinology
; 96(1): 32-40, 2012.
Article
em En
| MEDLINE
| ID: mdl-22205326
ABSTRACT
BACKGROUND:
Knowledge of clinical course in advanced jejunoileal neuroendocrine tumors (NETs) is poor.AIM:
To investigate progression-free survival (PFS), overall survival (OS), and possible predictors for disease progression (DP) in advanced jejunoileal NETs. PATIENTS ANDMETHODS:
We carried out a multicenter, retrospective analysis of incoming patients with sporadic advanced jejunoileal NETs. PFS and OS were assessed by Kaplan-Meier analysis. Risk factors for progression were analyzed by the Cox proportional hazards method.RESULTS:
Of the 114 patients enrolled, 46.5% had functioning tumors, 93.9% had stage IV disease, and 57.3 and 42.7% were G1 and G2 tumors, respectively. During a median follow-up of 48 months (interquartile range 29-84 months), DP occurred in 61.4% of patients, after 19 months (interquartile range 10-41 months) from diagnosis. Median PFS was 36 months. The 2-year and 5-year PFS were 59 and 33%, respectively, while 5-year OS was 77.5%. Ki67 was the sole strong independent risk factor for unfavorable outcome according to multivariate analysis, being significantly associated with both PFS and OS.CONCLUSIONS:
DP occurred in the majority of patients with advanced jejunoileal NETs, with median PFS being 36 months. Ki67 was a significant predictor of DP and should be considered in determining appropriate treatments and planning follow-up for these patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tumores Neuroendócrinos
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Antígeno Ki-67
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Neoplasias do Íleo
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Neoplasias do Jejuno
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article