Group B Streptococcus surface proteins as major determinants for meningeal tropism.
Curr Opin Microbiol
; 15(1): 44-9, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22206860
ABSTRACT
Streptococcus agalactiae (group B Streptococcus, GBS), a normal constituent of the intestinal microbiota is the major cause of human neonatal infections and a worldwide spread 'hypervirulent' clone, GBS ST-17, is strongly associated with neonatal meningitis. Adhesion to epithelial and endothelial cells constitutes a key step of the infectious process. Therefore GBS surface-anchored proteins are obvious potential adhesion mediators of barrier crossing and determinant of hypervirulence. This review addresses the most recent molecular insights gained from studies on GBS surface proteins proven to be involved in the crossing of the brain-blood barrier and emphasizes on the specificity of a hypervirulent clone that displays meningeal tropism.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptococcus agalactiae
/
Tropismo
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Fatores de Virulência
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Proteínas de Membrana
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Meninges
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article