MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children.
Oral Dis
; 18(4): 389-95, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22221294
ABSTRACT
OBJECTIVE:
The aim of the study was to examine whether the MBL2 C(-290)G and G161A, MASP2 A359G, AMELX C287T and C522T, and ENAM C2452T polymorphisms are associated with dental caries. SUBJECTS ANDMETHODS:
Genomic DNA of 95 Polish children with 'higher caries experience' (HC) and 84 subjects with 'lower caries experience' (LC) belonging to two age-groups (5 and 13 years old) was extracted from the buccal mucosa. SNPs were genotyped with PCR-RFLP methods.RESULTS:
Among 5-year-old children, we found significantly higher percentage of subjects carrying MBL2 (-290)G allele in HC group compared with LC group (43.2%vs 17.6%, P = 0.023). MBL2 C(-290)G-G161A C-G haplotype was overrepresented in LC group in 5-year-olds (P = 0.01), while the opposite association was observed in 13-year-olds, where C-G was overrepresented in HC group (P = 0.028). In 5-year-old children, the frequency of MBL2 G-G haplotype was higher in HC group compared with LC subjects (P = 0.045), while the opposite association (with borderline significance) was observed in 13-year-old children (P = 0.057). SNPs in MASP2, AMELX, and ENAM were not associated with dental caries.CONCLUSION:
MBL2 gene polymorphism is associated with caries experience in Polish children, but the direction of this association seems to be opposite in primary and permanent dentition.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
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Polimorfismo de Nucleotídeo Único
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Cárie Dentária
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Lectina de Ligação a Manose
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Serina Proteases Associadas a Proteína de Ligação a Manose
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Amelogenina
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child, preschool
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Female
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Humans
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article