Structure of N-formylglycinamide ribonucleotide amidotransferase II (PurL) from Thermus thermophilus HB8.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 1): 14-9, 2012 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-22232163
ABSTRACT
The crystal structure of PurL from Thermus thermophilus HB8 (TtPurL; TTHA1519) was determined in complex with an adenine nucleotide, PO(4)(3-) and Mg(2+) at 2.35 Å resolution. TtPurL consists of 29 α-helices and 28 ß-strands, and one loop is disordered. TtPurL consists of four domains, A1, A2, B1 and B2, and the structures of the A1-B1 and A2-B2 domains were almost identical to each other. Although the sequence identity between TtPurL and PurL from Thermotoga maritima (TmPurL) is higher than that between TtPurL and the PurL domain of the large PurL from Salmonella typhimurium (StPurL), the secondary structure of TtPurL is much more similar to that of StPurL than to that of TmPurL.
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Base de dados:
MEDLINE
Assunto principal:
Thermus thermophilus
/
Carbono-Nitrogênio Ligases com Glutamina como Doadora de N-Amida
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article