The relationship of electrocardiographic left ventricular hypertrophy to decreased serum potassium.
Blood Press
; 21(3): 146-52, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22243363
ABSTRACT
BACKGROUND:
Low serum potassium (K) is associated with increased blood pressure, impaired cardiac function and renal dysfunction. Although lower serum K is associated with cardiac hypertrophy in animal models, the relationship of low serum K to the presence and severity of electrocardiographic left ventricular hypertrophy (LVH) is unclear.METHODS:
Baseline and yearly Cornell product LVH levels were examined in relation to low serum K (serum K ≤ 3.90 mEq/l, the lowest quartile of baseline K levels) in 8586 patients with baseline K levels. Patients were randomized to losartan-vs atenolol-based treatment and additional hydrochlorothiazide (HCTZ) therapy as needed.RESULTS:
After adjusting for age, sex, race, prior antihypertensive treatment, losartan vs atenolol therapy, HCTZ use, baseline diastolic and systolic pressure, body mass index, serum creatinine and urine albumin/creatinine ratio, baseline serum K ≤ 3.90 was associated with significantly higher mean baseline Cornell product LVH (2898 vs 2801 mmâ¢ms, p = 0.001) and a 24% higher risk of Cornell product LVH > 2440 mmâ¢ms at baseline (OR 1.24, 95% CI 1.11-1.38, p < 0.001). After also adjusting for baseline Cornell product and changes in diastolic and systolic pressure between baseline and each year of measurement, in-treatment serum K ≤ 3.90 determined yearly was associated with significantly higher mean Cornell product LVH at years 1-3 and with statistically significant 16-32% increased risks of LVH by Cornell product at years 1-4.CONCLUSIONS:
A low serum K is independently associated with a greater likelihood and severity of Cornell product LVH during antihypertensive therapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipertrofia Ventricular Esquerda
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Hipertensão
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Hipopotassemia
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Anti-Hipertensivos
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article