A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.
Bioorg Med Chem
; 20(3): 1175-80, 2012 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-22257528
ABSTRACT
Acetylcholinesterase (AChE) enzyme inhibition is an important target for the management of Alzheimer disease (AD) and AChE inhibitors are the main stay drugs for its management. Coumarins are the phytochemicals with wide range of biological activities including AChE inhibition. The scientists have attempted to explore the coumarin template for synthesizing novel AChE inhibitors with additional pharmacological activities including decrease in beta-amyloid (Aß) deposition and beta-secretase inhibition that are also important for AD management. Most of the designed schemes have involved incorporation of a catalytic site interacting moiety at 3- and 4-positions of the coumarin ring. The present review describes these differently synthesized coumarin derivatives as AChE inhibitors for management of AD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Colinesterase
/
Cumarínicos
/
Doença de Alzheimer
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article