[Effect of Cordyceps sinensis sporocarp on learning-memory in mice].
Zhong Yao Cai
; 34(9): 1403-5, 2011 Sep.
Article
em Zh
| MEDLINE
| ID: mdl-22260011
ABSTRACT
OBJECTIVE:
To study the effect of extracts of Cordyceps sinensis sporocarp on learning-memory in scopolamine treated mice and the possible mechanism.METHODS:
ICR mice were randomly divided into five groups sham control, model, piracetam and CSE 0.5, 1 g/kg. Lotomotor activity was assessed. Morris water maze was used to evaluate the memory ability of mice 30 min later after ip scopolamine 1.0 mg/kg BW. Then acitivity of AchE was measured after behavioral test.RESULTS:
CSE had no influence on lotomotor activity. However, CSE 0.5, 1 g/kg both shortened escape latency and increased times of come-crossing platform in Morris water maze, meanwhile activity of AchE in the brain was decreased by CSE.CONCLUSION:
CSE can significantly improve the learning and memory impairment in mice induced by scopolamine, which may be correlated with the inhibition of activity of AchE.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Nootrópicos
/
Cordyceps
/
Deficiências da Aprendizagem
/
Transtornos da Memória
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article