Increased albuminuria in 4-year-old preterm-born children with normal height.
J Pediatr
; 160(6): 923-8.e1, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22261507
ABSTRACT
OBJECTIVE:
To determine risk factors for high blood pressure (BP), increased markers of glomerulosclerosis, and tubular dysfunction in 4-year-old preterm-born children. STUDYDESIGN:
The study group was a longitudinal cohort of 119 children with BP, albuminuria, and ß2 microglobulin measurements obtained during the neonatal period and at age 4 years.RESULTS:
Systolic BP was >95(th) percentile in 15 (12.6%) of the children at age 4 years and lower in those born small for gestational age compared with those born appropriate for gestational age. Preterm-born 4-year-olds with height <-1 SD had lower systolic and diastolic BP, and 14.4% of the 4-year-olds had albuminuria. Albuminuria was less prevalent in the 4-year-olds with height <-1 SD than in those with height ≥-1 SD (6.8% vs 19.3%; P=.04). Mean albuminuria level was 1.0±0.7 mg/mmol in 4-year-olds with height <-1 SD and 1.4±1.3 mg/mmol in those with height ≥-1 SD. In multivariate analysis, albuminuria level was increased by 0.4±0.2 mg/mmol in preterm-born children with normal height at age 4, and by 0.5±0.2 mg/mmol in females, after adjustment for gestational age, sex, neonatal morbidity, and intrauterine growth restriction. These results were unchanged after adjustment for body mass index.CONCLUSION:
Normal height at age 4 years may be associated with an increased risk for glomerulosclerosis in preterm-born children.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estatura
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Recém-Nascido Prematuro
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Glomerulosclerose Segmentar e Focal
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Albuminúria
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
/
Newborn
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article