Active conformation in amine-thiourea bifunctional organocatalysis preformed by catalyst aggregation.
Chemistry
; 18(7): 1918-22, 2012 Feb 13.
Article
em En
| MEDLINE
| ID: mdl-22262570
ABSTRACT
Self-activation Takemoto's catalyst gains access to its active conformation by equilibrating between its hydrogen-bonded intra- and intermolecular interactions in apolar aprotic solvents. By destabilization of the inactive monomeric conformations, the extended anti-anti thiourea conformation is preformed in the assembly. On leaving the assembly, this transient conformation has a structural preference to become a catalytically active monomeric species that has the potency for dual activation (see scheme).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tioureia
/
Aminas
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article