Your browser doesn't support javascript.
loading
RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway.
Shi, Shuo; Deng, Yue-Zhen; Zhao, Jiang-Sha; Ji, Xiao-Dan; Shi, Jun; Feng, Yu-Xiong; Li, Guo; Li, Jing-Jing; Zhu, Di; Koeffler, H Phillip; Zhao, Yun; Xie, Dong.
Afiliação
  • Shi S; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of Chinese Academy of Sciences, Shanghai 200031, China.
J Biol Chem ; 287(11): 7845-58, 2012 Mar 09.
Article em En | MEDLINE | ID: mdl-22262830
Non-small-cell lung cancer (NSCLC) is a deadly disease due to lack of effective diagnosis biomarker and therapeutic target. Much effort has been made in defining gene defects in NSCLC, but its full molecular pathogenesis remains unexplored. Here, we found RACK1 (receptor of activated kinase 1) was elevated in most NSCLC, and its expression level correlated with key pathological characteristics including tumor differentiation, stage, and metastasis. In addition, RACK1 activated sonic hedgehog signaling pathway by interacting with and activating Smoothened to mediate Gli1-dependent transcription in NSCLC cells. And silencing RACK1 dramatically inhibited in vivo tumor growth and metastasis by blocking the sonic hedgehog signaling pathway. These results suggest that RACK1 represents a new promising diagnosis biomarker and therapeutic target for NSCLC.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Biomarcadores Tumorais / Carcinoma Pulmonar de Células não Pequenas / Receptores de Superfície Celular / Proteínas de Ligação ao GTP / Proteínas Hedgehog / Neoplasias Pulmonares / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Biomarcadores Tumorais / Carcinoma Pulmonar de Células não Pequenas / Receptores de Superfície Celular / Proteínas de Ligação ao GTP / Proteínas Hedgehog / Neoplasias Pulmonares / Proteínas de Neoplasias Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2012 Tipo de documento: Article