Synthesis, structure and biological evaluation of novel bicyclic nitroimidazole derivatives.
Arch Pharm (Weinheim)
; 345(6): 463-7, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22266946
ABSTRACT
A new series of 3-hydroxy-8-nitroimidazo[5,1-b]-1,4,5,6-tetrahydropyrimidine systems, being potential tuberculostatic agents, were synthesized. These products are close structural analogs of the basic structure of the known antitubercular bicyclic nitroimidazooxazine PA-824. The structures of the products obtained were confirmed by X-ray methods on the example of 3-hydroxy-8-nitro-1-phenylaminoimidazo[5,1-b]-1,4,5,6-tetrahydropyrimidine. Evaluation of these products for their anti-tuberculosis effects revealed interesting structure-activity relationships.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Bicíclicos Heterocíclicos com Pontes
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Mycobacterium tuberculosis
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Nitroimidazóis
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Antituberculosos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article