Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin.
Nat Chem Biol
; 8(3): 232-4, 2012 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-22267119
ABSTRACT
Neuropathic pain is a debilitating condition for which the development of effective treatments has been limited by an incomplete understanding of its chemical basis. We show by using untargeted metabolomics that sphingomyelin-ceramide metabolism is altered in the dorsal horn of rats with neuropathic pain and that the upregulated, endogenous metabolite N,N-dimethylsphingosine induces mechanical hypersensitivity in vivo. These results demonstrate the utility of metabolomics to implicate unexplored biochemical pathways in disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esfingolipídeos
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Metabolômica
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Dor Crônica
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Neuralgia
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article