Influence of obesity-susceptibility loci (MC4R and INSIG2) on the outcome of weight loss and amelioration of co-morbidity in obese patients treated by a gastric-bypass.
Bull Soc Sci Med Grand Duche Luxemb
; (2): 7-24, 2011.
Article
em En
| MEDLINE
| ID: mdl-22272442
ABSTRACT
BACKGROUND:
Genome-wide association and linkage studies have identified multiple susceptibility loci for obesity.OBJECTIVE:
We hypothesized that such loci may affect weight loss and comorbidity amelioration outcomes following a gastric-bypass.DESIGN:
A total of 200 obese patients who underwent a gastric bypass surgery were genotyped for single-nucleotide polymorphisms (SNPs) in insulin induced gene 2 (INSIG2) and melanocortin 4 receptor (MC4R) obesity genes.RESULTS:
After a follow-up of 18 month, the patients (192) data of weight excess loss (72%) and co-morbidities (Hypertension -62- and Diabetes -39-) were analyzed and compared. 26 Patients with SNP were found (9 MC4R and 17 INSIG2). No significant differences in weight excess loss and amelioration of comorbidities were revealed.CONCLUSIONS:
The data suggest no influence of weight excess loss and amelioration of co-morbidities after gastric-bypass by genetic susceptibility.
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Base de dados:
MEDLINE
Assunto principal:
Redução de Peso
/
Polimorfismo de Nucleotídeo Único
/
Receptor Tipo 4 de Melanocortina
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Proteínas de Membrana
/
Obesidade
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article