Patients with thymomas have an increased risk of developing additional malignancies: lack of immunological surveillance?
Histopathology
; 60(3): 437-42, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22276606
ABSTRACT
AIMS:
To assess the risk, for patients with thymoma, of developing an additional malignancy (AM). METHODS ANDRESULTS:
We studied 68 patients with thymomas. Based on the World Health Organization classification, the tumours were categorised as A, AB or B (B1, B2, B3) thymomas. Control populations comprised 114 patients with colorectal cancer, 108 patients with lymphoma and 123 patients with thyroid carcinoma. Patients with thymomas showed a higher risk of developing an AM (22 of 68 patients versus 11 of 114, eight of 108, and eight of 123 patients, respectively; P = 0.0002). The association between thymomas and AMs was related to the thymoma histotype, with B1, B2, B3 and AB tumours showing a higher risk of developing an AM than A thymomas (P = 0.0474).CONCLUSIONS:
Patients affected by thymomas showed a significantly higher risk of developing additional malignancies than those in the control groups, and cases that exhibited a predominantly cortical component were more likely to develop other neoplasms. This may be related to the functions of cortical thymic epithelial cells in providing for T lymphocyte maturation through interaction with major histocompatibility complexes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timoma
/
Neoplasias do Timo
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Hospedeiro Imunocomprometido
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Vigilância Imunológica
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Neoplasias Primárias Múltiplas
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article