t(6;9)(p23;q34) presenting acute myeloid leukemia in a child with an unsuspected 45,X/46,X,derY [?t(Yp;Yq)] chromosomal constitution: yet another Y chromosome overdosage and malignancy association.
J Pediatr Hematol Oncol
; 34(6): e237-40, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22278197
ABSTRACT
Development of leukemia in patients with sexual chromosome abnormalities is relatively rare and mostly involves cases of monosomy X, Turner syndrome. Here, we report on a child having a 45,X/46,X,derY [?t(Yp;Yq)] chromosomal constitution (variant Turner syndrome) presenting with concordant acute myeloid leukemia and a rarely seen clonal neoplasic cell lineage-related karyotype, t(6;9)(p23;q34).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Síndrome de Turner
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Cromossomos Humanos Par 6
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Cromossomos Humanos Par 9
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Leucemia Mieloide Aguda
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Aberrações Cromossômicas
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Cromossomos Humanos Y
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article