Mouse models of human bladder cancer as a tool for drug discovery.
Curr Protoc Pharmacol
; Chapter 14: Unit14.14, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-22294368
ABSTRACT
Muscle-invasive bladder cancer is a deadly condition in dire need of effective new treatments. This unit contains a description of mouse models suitable for the evaluation of potential new therapies. Included is a genetically engineered mouse model of bladder cancer generated by the delivery of an adenovirus expressing Cre recombinase into the bladder lumen. Also described is an orthotopic mouse model created by the instillation of human bladder tumor cells into the bladder lumen of immune deficient mice. Protocols are also provided on the use of these models for the preclinical evaluation of new chemical entities, with mTOR inhibitors shown as an example.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Modelos Animais de Doenças
/
Descoberta de Drogas
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Antineoplásicos
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article