Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls.
Aging Male
; 15(1): 59-62, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22303889
ABSTRACT
BACKGROUND:
Age related bone loss is widely accepted as related to decreased serum levels of circulating sex hormones. Epidemiological data also show distal radius fractures in men to be a sensitive marker of bone fragility. The aim of this study was to assess if men with a history of distal radius fracture have lower bone mass density (BMD), lower free androgen index (FAI), lower total testosterone (T) and lower bio-available testosterone (Bio-T) than healthy age-matched controls. PATIENTS ANDMETHODS:
A case-control study is based on consecutive cases treated for low energy distal radius fracture at our department and age-matched controls. Thirty-nine men treated between 1997-2004 and 45 age-matched controls underwent calcaneal bone density measurements (t-score) and analyses of T, Bio-T and serum hormone binding globulin (SHBG).RESULTS:
The fracture group had lower BMD (p < 0.01) and lower FAI (p = 0.01). Linear regression analysis showed a correlation between Bio-T and t-scores (p = 0.03). Using analysis of covariance, a significant difference with lower Bio-T in the fracture group was shown.CONCLUSION:
Bio-T seems to correlate with BMD in elderly men and may serve as a marker for increased fracture risk in this patient group.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Calcâneo
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
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Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article