Synthesis and biological activities of novel isoxazoline-linked pseudodisaccharide derivatives.
Carbohydr Res
; 351: 7-16, 2012 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-22305409
ABSTRACT
A series of novel isoxazoline linked pseudodisaccharide derivatives were regiospecifically synthesized by 1,3-dipolar cycloaddition of α-allyl-C-glycopyranosides and sugar-derived nitrile oxides with good yields. The structures of the compounds were characterized by NMR spectroscopy and MS spectrometry and confirmed by the X-ray crystallographic analysis of compound ((5S)-3-(2,3-O-isopropylidene-5-deoxy-d-lyxofuranose-4-yl)isoxazoline-5-yl) methyl α- C-D-galactopyranoside. Their biological activities against glycosidases (α-amylase, α-glucosidase, and ß-glucosidase) and HIV-RT, and antitumor activity were preliminarily evaluated. Some of them exhibited potent inhibitory activity to HIV-RT.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Transcriptase Reversa
/
Dissacarídeos
/
Isoxazóis
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article