Precocious puberty and empty sella syndrome in a girl cured of acute lymphoblastic leukemia.
J Pediatr Endocrinol Metab
; 24(11-12): 1067-9, 2011.
Article
em En
| MEDLINE
| ID: mdl-22308868
ABSTRACT
We describe a case of precocious puberty in a girl treated with chemoradiotherapy according to the Italian Association of Pediatric Hematology and Oncology ALL 9503 protocol for acute lymphoblastic leukemia (ALL) from the age of 15 months until the age of 3 years and 4 months. The patient was treated with chemotherapy and cranial irradiation (18 Gy in 12 fractions). At 7 years of age, during topical estrogenic treatment for congenital adhesions of the labia minora, she showed bilateral breast development that evolved into precocious puberty. A magnetic resonance imaging of the brain showed an "empty sella" (ES); the etiology of the ES, and the consequent precocious puberty, being presumably iatrogenic. Children treated with cranial radiotherapy should be carefully checked for signs of precocious puberty and the exogenous administration of estrogens should be avoided, as far as possible, because these could act as a trigger factor in a population at higher risk of precocious puberty.
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Base de dados:
MEDLINE
Assunto principal:
Puberdade Precoce
/
Síndrome da Sela Vazia
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Quimiorradioterapia
Tipo de estudo:
Guideline
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article