Ferric reducing, antiradical and beta-carotene bleaching activities of nicotinic acid and picolinic acid bioconjugates of curcumin.
Nat Prod Commun
; 6(12): 1877-80, 2011 Dec.
Article
em En
| MEDLINE
| ID: mdl-22312728
ABSTRACT
Although curcumin displays several beneficial properties, its medicinal use is limited by its low bioavailability. In the present study we report the antioxidant potentials of two bioconjugates of curcumin with nicotinic acid and picolinic acid di-O-nicotinoyl curcumin [1,7-bis (4-O nicotinoyl-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione] and di-O-picolinoyl curcumin [1,7-bis (4-O-picolinoyl-3-methoxyphenyl)-1,6-heptadiene-3, 5-dione], in terms of ferric reducing, radical scavenging and beta-carotene bleaching abilities, and comparing the observed activity with that of curcumin. Results demonstrate that both the bioconjugates possess higher antioxidant potentials as evidenced by enhanced ferric reducing, radical scavenging and beta-carotene bleaching abilities, in comparison with curcumin. On the basis of our results we conclude that these bioconjugates of curcumin may be better than curcumin for medicinal and pharmacological applications.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Picolínicos
/
Sequestradores de Radicais Livres
/
Beta Caroteno
/
Curcumina
/
Ácidos Nicotínicos
/
Antioxidantes
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article