[Novel mutations of cardiac troponin T in Chinese patients with hypertrophic cardiomyopathy].
Zhonghua Xin Xue Guan Bing Za Zhi
; 39(10): 909-14, 2011 Oct.
Article
em Zh
| MEDLINE
| ID: mdl-22321274
ABSTRACT
OBJECTIVE:
To screen the cardiac troponin T (TNNT2) mutations in Chinese patients with hypertrophic cardiomyopathy (HCM) and to analyze the potential link between the genotype and the phenotype.METHODS:
Clinical features of 100 probands with HCM and some family members were evaluated, 200 unrelated normal subjects served as control. The exons and flanking introns of TNNT2 were amplified with PCR and direct sequencing was used to screen TNNT2 mutations/polymorphisms.RESULTS:
Two novel missense mutations were detected in 2 HCM patients R92W and R286H. These 2 mutations were not found in 200 non-HCM controls. A five-basepair insertion/deletion polymorphism in intron 3 of TNNT2 was identified in this HCM cohort but was not related to the phenotype.CONCLUSIONS:
Two missense mutations, R92W and R286H, were found in 2/100 patients with HCM, TNNT 2 mutation is relatively low in Chinese patients with HCM.
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Base de dados:
MEDLINE
Assunto principal:
Cardiomiopatia Hipertrófica
/
Troponina T
/
Mutação
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article