[Post-radiation atypical vascular lesions and angiosarcoma: 11 cases]. / Lésions vasculaires atypiques et angiosarcomes post-radiothérapie : 11 cas.
Ann Dermatol Venereol
; 139(2): 109-17, 2012 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-22325749
ABSTRACT
BACKGROUND:
Post-radiation atypical vascular lesions of the skin display clinical and morphological overlap with well-differentiated angiosarcomas, and correct diagnosis may be difficult. PATIENTS ANDMETHODS:
We studied clinical, histological and immuno-histochemical aspects (CD31, CD34, D2-40 and VEGFR-3) of eight post-radiation atypical vascular lesions comparatively with three post-radiation angiosarcomas.RESULTS:
All patients were female and received radiation therapy for breast carcinoma. On average, atypical vascular lesions occurred 4.3 years after radiation therapy and presented as small papulonodules or erythematous plaques. The clinical course after simple excision was benign. Histologically, they were relatively circumscribed lesions and showed slit-like vessels dissecting dermal collagen in all cases. On average, angiosarcomas occurred 5 years after radiation therapy and presented as more extensive lesions with a more aggressive clinical course. The lesions showed histological overlap with atypical vascular lesions, but were poorly circumscribed, with deeper invasion, cytological atypia and mitosis. Although the immuno-histochemical profiles were similar, expression of VEGFR-3 was greater in two cases of angiosarcoma.CONCLUSION:
Post-radiation atypical vascular lesions are benign lesions that display clinical, histological and immuno-phenotypic overlap with well-differentiated angiosarcoma, and diagnosis requires good clinicopathological correlation. VEGFR-3 may be useful for differential diagnosis, as well as amplification of the MYC gene.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
/
Neoplasias Cutâneas
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Dermatopatias Vasculares
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Hemangiossarcoma
/
Neoplasias Induzidas por Radiação
Limite:
Aged
/
Aged80
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Female
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Humans
Idioma:
Fr
Ano de publicação:
2012
Tipo de documento:
Article