[Change of serum TGF-beta1 and TNF-alpha in silicosis patients].
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
; 29(8): 606-7, 2011 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-22335161
ABSTRACT
OBJECTIVE:
To observe serum TGF-beta1 and TNF-alpha in silicosis patients and workers exposed to silica dust to study the role of TGF-beta1 and TNF-alpha in the development of silicosis.METHODS:
One hundred non-exposed workers were selected as control group, 200 workers exposed to silica dust for more than 1 year as exposed group, 32 suspected silicosis patients (originally diagnosed as 0+) as observing group, 130 silicosis patients were as silicosis group. Serum TGF-beta1 and TNF-alpha in each group were determined with ELISA.RESULTS:
Serum TNF-alpha in exposed group [(47.86 +/- 16.52) pg/ml], observing group [(109.11 +/- 31.08) pg/ml], silicosis group [(216.35 +/- 51.03) pg/ml] were significantly higher than that in control group [(6.90 +/- 2.24) pg/ml] (P < 0.01); Silicosis group and observing group were also higher than exposed group (P < 0.01, P < 0.05). Compared with control group [(23.28 +/- 12.24) pg/ml] and exposed group [(29.31 +/- 14.52) pg/ml], serum TGF-beta1 in silicosis group was much higher (P < 0.01).CONCLUSION:
TGF-beta1, and TNF-alpha were essential in the development of silicosis, so the detection of TGF-beta1 and TNF-alpha in peripheral blood was very useful for occupational health surveillance and early diagnosis of silicosis.
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Base de dados:
MEDLINE
Assunto principal:
Silicose
/
Fator de Necrose Tumoral alfa
/
Fator de Crescimento Transformador beta1
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article