Halothane changes the domain structure of a binary lipid membrane.
Langmuir
; 28(10): 4723-8, 2012 Mar 13.
Article
em En
| MEDLINE
| ID: mdl-22352350
ABSTRACT
X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibria of a lipid mixture.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Halotano
/
Lipídeos de Membrana
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article