Stability of toxigenicity in proteolytic Clostridium botulinum type B upon serial passage.

Umeda, Kaoru; Seto, Yoshiyuki; Kohda, Tomoko; Mukamoto, Masafumi; Kozaki, Shunji

Umeda, Kaoru; Seto, Yoshiyuki; Kohda, Tomoko; Mukamoto, Masafumi; Kozaki, Shunji.

Afiliação

Umeda K; Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan.

Microbiol Immunol ; 56(5): 338-41, 2012 May.

Article em En | MEDLINE | ID: mdl-22352877

ABSTRACT

ABSTRACT

Proteolytic Clostridium botulinum type B strains were investigated for stability of toxigenicity and bont/b gene upon serial passage. Strains with bont/b gene located on their plasmids showed loss or decrease of toxigenicity during serial passage. Some strains lost the bont/b gene-encoding plasmid. The stability of the plasmids varied between strains.

Assuntos

Toxinas Botulínicas/genética; Botulismo/microbiologia; Clostridium botulinum tipo B/genética; Clostridium botulinum tipo B/patogenicidade; Toxinas Botulínicas/metabolismo; Toxinas Botulínicas/toxicidade; Clostridium botulinum tipo B/química; Clostridium botulinum tipo B/metabolismo; Humanos; Plasmídeos/genética; Plasmídeos/metabolismo; Inoculações Seriadas; Virulência

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Toxinas Botulínicas / Botulismo / Clostridium botulinum tipo B Limite: Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article

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