Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma.
Biochem Biophys Res Commun
; 419(3): 490-4, 2012 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-22366088
ABSTRACT
Cancer is associated with increased glycolysis and carbonyl stress. In view of this, AGE modified proteins were identified from clinical breast cancer tissue using 2DE-immunoblot and mass-spectrometry. These proteins were identified to be serotransferrin, fibrinogen gamma chain, glycerol-3-phosphate dehydrogenase, lactate dehydrogenase, annexin II, prohibitin and peroxiredoxin 6, which have established role in cancer. Further, RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB were studied. Role of these AGE modified proteins and RAGE signaling in breast cancer is discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Produtos Finais de Glicação Avançada
/
Carcinoma Ductal de Mama
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Proteínas Quinases Ativadas por Mitógeno
/
Receptor para Produtos Finais de Glicação Avançada
/
Proteínas de Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article