Characterization of metalloproteinases, oxidative status and inflammation levels in the different stages of fibrosis in HCV patients.
Clin Biochem
; 45(7-8): 525-9, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22366372
ABSTRACT
OBJECTIVES:
This study was aimed at searching noninvasive markers of the transition from mild to severe fibrosis stage in HCV patients undergoing hepatic fibrosis. DESIGN ANDMETHODS:
Thirty-three patients affected by chronic HCV vs. twenty healthy donors were evaluated for the serum levels of several circulating matrix metalloproteinases (MMPs), TRAIL and ß-NGF by multiplex biometric ELISA based immunoassay and anti- and pro-oxidant status (d-ROMs, BAP and NO) using a Diacron automated method.RESULTS:
HCV patients displayed increased expression levels of MMP-8, MMP-9, TRAIL and ß-NGF, and an imbalance between pro- and antioxidant status, that contribute to liver fibrosis.CONCLUSIONS:
Since the determination of these parameters represents a reliable and easily applicable method, these parameters are suggested as serum surrogate markers for HCV patients in the routine clinical practice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
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Hepatite C Crônica
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Metaloproteinase 9 da Matriz
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Metaloproteinase 8 da Matriz
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Inflamação
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Cirrose Hepática
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article