Building the niche: the role of the S100 proteins in metastatic growth.
Semin Cancer Biol
; 22(3): 216-25, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22381352
ABSTRACT
Communication between cancer cells and stromal cells, often mediated by extracellular molecules in the tumor microenvironment, plays a central role in tumorigenesis and metastasis. The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+-binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. Focusing on S100A4, S100A8 and S100A9, in this review we discuss the role these proteins play in primary tumors and in the development of metastases, in particular during the formation of pre-metastatic niches.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas S100
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Transformação Celular Neoplásica
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Células Estromais
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Microambiente Tumoral
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Inflamação
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Metástase Neoplásica
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article