Detection of circulating immune complexes in MRL mice with different forms of glomerulonephritis.
Z Versuchstierkd
; 33(4): 149-56, 1990.
Article
em En
| MEDLINE
| ID: mdl-2238887
ABSTRACT
Serum levels of circulating immune complexes (CIC) in MRL mice were determined using the 125I-C1q binding test and a conglutinin enzyme assay. The serum 125I-C1q and conglutinin binding capacity were correlated to the development of different forms of glomerulonephritis (GN) detected by light microscopy. The study was carried out with a total of 132 MRL/MpJ-lpr/lpr and MRL/MpJ(-)+/+ mice of different age groups. From the age of 3 months on an enormous elevation of C1q- and conglutinin-binding CIC occurred in MRL/MpJ-lpr/lpr mice, while in MRL/MpJ(-)+/+ mice the mean values of CIC remained low in all age groups studied. The results corresponded to histopathological glomerular findings. In lpr/lpr-mice, from the age of 3 months on, extremely severe proliferative forms of GN occurred. In most cases of +/+(-)mice examined comparatively mild glomerular lesions were found. In serum samples of HanNMRI and C3H/He mice an increase of conglutinin-binding material was found in certain age groups, while the levels of 125I-C1q binding activity remained low in mice of all age groups studied.
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Base de dados:
MEDLINE
Assunto principal:
Doenças dos Roedores
/
Glomerulonefrite
/
Camundongos Endogâmicos
/
Complexo Antígeno-Anticorpo
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article