A simple synthesis of N-perfluoroacylated and N-acylated glycals of neuraminic acid with a cyclic aminic substituent at the 4α position as possible inhibitors of sialidases.
Org Biomol Chem
; 10(14): 2885-94, 2012 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-22395901
ABSTRACT
A simple protocol for the synthesis of N-perfluoroacylated and N-acylated glycals of neuraminic acid, with a secondary cyclic amine (morpholine or piperidine) at the 4α position, has been set-up, starting from peracetylated N-acetylneuraminic acid methyl ester that undergoes, sequentially to its direct N-transacylation followed by a C-4 amination, a ß-elimination, and a selective hydrolysis of the ester functions, without affecting the sensitive perfluorinated amide.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carboidratos
/
Compostos de Flúor
/
Inibidores Enzimáticos
/
Éter
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Aminas
/
Ácidos Neuramínicos
/
Neuraminidase
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article