Relationship of oxygen dose to angiogenesis induction in irradiated tissue.
Am J Surg
; 160(5): 519-24, 1990 Nov.
Article
em En
| MEDLINE
| ID: mdl-2240387
ABSTRACT
This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p = 0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p = 0.001). Irradiated tissue develops a hypovascular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Lesões Experimentais por Radiação
/
Circulação Colateral
Limite:
Animals
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article