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3-Hy-droxy-2,2-bis-(1H-pyrazol-1-yl)-cyclo-penta-none.
Rybakov, Victor B; Utkina, Anastasia A; Kurkin, Alexander V; Yurovskaya, Marina A.
Afiliação
  • Rybakov VB; Department of Chemistry, Moscow State University, 119992 Moscow, Russian Federation.
Acta Crystallogr Sect E Struct Rep Online ; 68(Pt 3): o844, 2012 Mar 01.
Article em En | MEDLINE | ID: mdl-22412705
The title compound, C(11)H(12)N(4)O(2), was unexpectedly obtained in the reaction of α,α'-disubstituted cyclo-penta-none with 1,1,3,3-tetra-meth-oxy-propane in the presence of dioxane saturated with HCl. It belongs to a previously unknown class of gem-bihetaryl ketones which may be useful for screening of new substances with biological activity. In the studied structure, the cyclo-penta-none moiety adopts an envelope conformation, with the hy-droxy-bearing C atom as the flap [deviation from basal plane = 0.643 (3) Å]. The dihedral angle between the two pyrazole rings is 80.02 (8)°. In the crystal, inversion dimers are formed via a pair of O-H⋯N hydrogen bonds.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2012 Tipo de documento: Article