Benzylic phosphates as electrophiles in the palladium-catalyzed asymmetric benzylation of azlactones.
J Am Chem Soc
; 134(13): 5778-81, 2012 Apr 04.
Article
em En
| MEDLINE
| ID: mdl-22420708
ABSTRACT
Palladium-catalyzed asymmetric benzylation has been demonstrated with azlactones as prochiral nucleophiles in the presence of chiral bisphosphine ligands. Benzylic electrophiles are utilized under two sets of reaction conditions to construct a new tetrasubstituted stereocenter. Electron density of the phenyl ring dictates the reaction conditions, including the leaving group. The reported methodology represents a novel asymmetric carbon-carbon bond formation in an amino acid precursor.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article