Life in the fast lane: mammalian disease models in the genomics era.
Cell
; 148(6): 1099-109, 2012 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-22424222
ABSTRACT
Analyses of the human genome have proven extremely successful in identifying changes that contribute to human disease. Genetically engineered mice provide a powerful tool to analyze these changes, although they are slow and costly and do not always recapitulate human biology. Recent advances in genomic technologies, rodent-modeling approaches, and the production of patient-derived reprogrammed cell lines now provide a plethora of complementary systems to study disease states and test new therapies. Continued evolution and integration of these model systems will be the key to realizing the benefits of the genomic revolution and refining our understanding and treatment of human diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Modelos Animais de Doenças
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article