Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L.
Exp Parasitol
; 131(1): 130-2, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22426246
ABSTRACT
Chagas disease is caused by Trypanosoma cruzi, being considered a public health problem. An alternative to combat this pathogen is the use of natural products isolated from fruits such as Eugenia uniflora, a plant used by traditional communities as food and medicine due to its antimicrobial and biological activities. Ethanolic extract from E. uniflora was used to evaluate in vitro anti-epimastigote and cytotoxic activity. This is the first record of anti-Trypanosoma activity of E. uniflora, demonstrating that a concentration presenting 50% of activity (EC(50)) was 62.76 µg/mL. Minimum inhibitory concentration (MIC) was ≤ 1024 µg/mL. Our results indicate that E. uniflora could be a source of plant-derived natural products with anti-epimastigote activity with low toxicity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma cruzi
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Extratos Vegetais
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Syzygium
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Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article