The potential usage of caffeic acid phenethyl ester (CAPE) against chemotherapy-induced and radiotherapy-induced toxicity.
Cell Biochem Funct
; 30(5): 438-43, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22431158
ABSTRACT
Protection of the patients against the side effects of chemotherapy and radiotherapy regimens has attracted increasing interest of clinicians and practitioners. Caffeic acid phenethyl ester (CAPE), which is extracted from the propolis of honeybee hives as an active component, specifically inhibits nuclear factor κB at micromolar concentrations and show ability to stop 5-lipoxygenase-catalysed oxygenation of linoleic acid and arachidonic acid. CAPE has antiinflammatory, antiproliferative, antioxidant, cytostatic, antiviral, antibacterial, antifungal and antineoplastic properties. The purpose of this review is to summarize in vivo and in vitro usage of CAPE to prevent the chemotherapy-induced and radiotherapy-induced damages and side effects in experimental animals and to develop a new approach for the potential usage of CAPE in clinical trial as a protective agent during chemotherapy and radiotherapy regimens.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Álcool Feniletílico
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Ácidos Cafeicos
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Protocolos de Quimioterapia Combinada Antineoplásica
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Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article