Modulation of proteasome machinery by natural and synthetic analogues of the marine bioactive compound petrosaspongiolide M.
Chembiochem
; 13(7): 982-6, 2012 May 07.
Article
em En
| MEDLINE
| ID: mdl-22438326
ABSTRACT
Natural or synthetic? Several petrosaspongiolide M natural and synthetic analogues have been tested as proteasome inhibitors and apoptosis modulators. The natural petrosaspongiolide M congeners gave a consistent decrease in activity. Among the synthetic analogues, the introduction of the benzothiophene ring resulted in a bioequivalent alternative of the petrosaspongiolide M terpenoid system.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Oleanólico
/
Fosfolipases A
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Inibidores de Proteassoma
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Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article