Development of invasive colon cancer with microsatellite instability in a patient with hyperplastic polyposis syndrome.
Jpn J Clin Oncol
; 42(5): 451-4, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22438407
ABSTRACT
The serrated pathway has recently been proposed as a route for the development of colorectal cancer with microsatellite instability. Hyperplastic polyposis syndrome is a rare syndrome defined by the presence of numerous serrated polyps, with a high risk of developing into colorectal cancer. We present here a case of hyperplastic polyposis syndrome developing into colorectal cancer with microsatellite instability from a serrated polyp. BRAF mutation and the loss of MLH1 protein were observed in the colorectal cancer, but not in the other serrated polyps around the colorectal cancer, suggesting that colorectal cancer with microsatellite instability develops rapidly from a specific serrated polyp with distinct molecular properties.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
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Transformação Celular Neoplásica
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Pólipos do Colo
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Neoplasias do Colo
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Proteínas Proto-Oncogênicas B-raf
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Instabilidade de Microssatélites
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article