Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku.
Rheumatol Int
; 33(9): 2411-5, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-22453528
ABSTRACT
Camptocormia, an abnormal truncal flexion posture that occurs while walking or standing, is usually caused by various hypokinetic movement disorders, mainly Parkinson disease. We describe the case of a man with subacute onset of camptocormia. Quadriceps muscle biopsy showed significant rhabdomyolysis, few isolated inflammatory cells and mild expression of type I MHC in few fibers, a pattern usually found in immune-mediated necrotizing myopathies. Myositis was associated with Raynaud's phenomenon, mild sclerodactyly, and anti-Ku antibodies leading to the diagnosis of polymyositis/systemic sclerosis overlap myositis. The posture showed modest improvement in response to treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Escleroderma Sistêmico
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Autoanticorpos
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Curvaturas da Coluna Vertebral
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Atrofia Muscular Espinal
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Polimiosite
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Antígenos Nucleares
/
Proteínas de Ligação a DNA
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Humans
/
Male
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article