Clinical stage of Merkel cell carcinoma and survival are not associated with Breslow thickness of biopsied tumor.
Dermatol Surg
; 38(8): 1351-6, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22455371
ABSTRACT
BACKGROUND:
Merkel cell carcinoma (MCC) is an aggressive malignancy that often presents on the skin with concurrent metastatic disease.OBJECTIVE:
To determine whether Breslow thickness of biopsied MCC correlates with clinical disease stage. MATERIALS ANDMETHODS:
We performed a retrospective review of clinical data and histopathology specimens from 34 individuals with MCC treated at the Roswell Park Cancer Institute for whom complete clinical information and histopathology specimens were available.RESULTS:
There was no correlation between Breslow thickness of biopsied MCC on the head and neck or body and clinical stage of disease, progression-free survival, or overall survival. Hence, thin MCCs should not be taken to represent lesions with less-aggressive clinical behavior.CONCLUSION:
Our findings validate the current practice of staging all newly diagnosed MCC, irrespective of size or Breslow thickness.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma de Célula de Merkel
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article