Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients.
J Neuroimmunol
; 246(1-2): 100-7, 2012 May 15.
Article
em En
| MEDLINE
| ID: mdl-22465063
ABSTRACT
CS-0777 is a selective sphingosine 1-phosphate receptor-1 modulator under investigation for treatment of multiple sclerosis (MS). We conducted an open-label, pilot study in 25 MS patients to assess the safety, pharmacokinetics, pharmacodynamics and exploratory efficacy of oral CS-0777 (0.1, 0.3 and 0.6 mg), administered once weekly or every other week for 12 weeks. CS-0777 resulted in a pronounced, dose-dependent decrease in lymphocytes and CD4 T cell subsets, which returned to baseline within 4 weeks after the last dose. Overall, CS-0777 was safe and well-tolerated. These results require confirmation in a double-blind, placebo-controlled and adequately powered phase 2 study in MS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
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Esfingosina
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Lisofosfolipídeos
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Receptores de Lisoesfingolipídeo
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Amino Álcoois
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Esclerose Múltipla
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article