Sensorineural hearing loss: a reversible effect of valproic acid.

Armon, C; Brown, E; Carwile, S; Miller, P; Shin, C

Armon, C; Brown, E; Carwile, S; Miller, P; Shin, C.

Afiliação

Armon C; Department of Medicine (Neurology), Duke University Medical Center, Durham, NC.

Neurology ; 40(12): 1896-8, 1990 Dec.

Article em En | MEDLINE | ID: mdl-2247241

ABSTRACT

ABSTRACT

We report 2 patients over the age of 70 who, while on valproate (VPA) for complex partial seizures, developed sensorineural hearing loss. Following discontinuation of VPA for nonaudiologic reasons, the patients reported improved hearing which was confirmed by audiometry. These findings represent VPA-induced sensorineural hearing loss, possibly in preexisting presbycusis.

Assuntos

Perda Auditiva Neurossensorial/induzido quimicamente; Ácido Valproico/efeitos adversos; Idoso; Audiometria; Epilepsia do Lobo Temporal/tratamento farmacológico; Perda Auditiva Neurossensorial/fisiopatologia; Humanos; Masculino; Fenobarbital/uso terapêutico; Fenitoína/uso terapêutico; Remissão Espontânea; Ácido Valproico/uso terapêutico

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Base de dados: MEDLINE Assunto principal: Ácido Valproico / Perda Auditiva Neurossensorial Limite: Aged / Humans / Male Idioma: En Ano de publicação: 1990 Tipo de documento: Article

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