Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.
J Org Chem
; 77(9): 4198-208, 2012 May 04.
Article
em En
| MEDLINE
| ID: mdl-22489775
ABSTRACT
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Vinila
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Cianobactérias
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Neurotransmissores
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article