[Alterations of plasma aspartic acid, glycine and asparagine levels in patients with major depressive disorder].
Zhejiang Da Xue Xue Bao Yi Xue Ban
; 41(2): 132-8, 2012 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-22499508
OBJECTIVE: To evaluate the changes of plasma levels of the excitatory amino acid neurotransmitter aspartic acid (Asp), inhibitory neurotransmitter glycine (Gly) and asparagine (Asn) in patients with major depressive disorder (MDD). METHODS: Plasma samples were collected from 15 MDD patients (9 males and 6 females, aged 32-64 y) and 14 healthy subjects (7 males and 7 females, aged 30-65 y); and also collected from 7 MDD patients (5 males and 2 females) 2 months after antidepressant treatment. The plasma levels of amino acids were determined by high performance liquid chromatography with fluorescence detection method. RESULTS: Plasma Asp and Gly levels were significantly lower in MDD patients than those in controls (P<0.04). There were positive correlations between plasma levels of Gly and Asp, and between Gly and Asn (P<0.005) in the control group; while in MDD patients, a significant positive correlation was found only between plasma levels of Gly and of Asp (P<0.001). MDD patients did not show significant changes in plasma Asp, Asn and Gly levels after antidepressant treatment compared to those before treatment. CONCLUSION: The reduced plasma Asp and Gly levels may serve as a clinical biomarker for MDD.
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Base de dados:
MEDLINE
Assunto principal:
Asparagina
/
Ácido Aspártico
/
Transtorno Depressivo Maior
/
Glicina
Limite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2012
Tipo de documento:
Article